Adult mesenchymal stem cells (MSCs) can be isolated from bone marrow or marrow aspirates and because they are culture-dish adherent,
they can be expanded in culture while maintaining their multipotency.
Biologic and clinical interest in MSC has risen dramatically over the last two decades, as shown by the ever-increasing number of research teams studying these cells. Not only are established laboratories focusing on MSC but new investigators are rapidly being attracted to the field, which will undoubtedly accelerate scientific discovery and the development of novel cellular therapies.
Mesenchymal stem cells (MSCs) are partially defined by their ability to differentiate into tissues including bone, cartilage and
adipose in vitro, but it is their trophic, paracrine and immunomodulatory functions that may have the greatest therapeutic
impact in vivo.
Tissue engineering is a rapidly evolving discipline that seeks to repair, replace, or regenerate specific tissues or organs by translating fundamental knowledge in physics, chemistry, and biology into practical and effective materials, devices, systems, and clinical strategies.